Mechanism of Action

Although the mechanism of silicone gel for scar treatment remains unknown, studies suggest that silicone gel sheeting improves scarring because it is semi-occlusive and enhances the water barrier function of the stratum corneum (the outermost layer of the skin) on the immature scar. Dermatix™ Ultra also forms a semi-occlusive sheet that promotes tissue hydration and provides an occlusive barrier to the skin. Silicone also modifies fibroblasts that are involved in scarring process and which break down collagen. There is the suggestion that silicone gel helps modulate the basic fibroblast growth factor levels and may help in the more organized deposition and alignment of collagen.¹